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Renal function impairment
Cases of Systemic Nephrogenic Fibrosis (NSF) have been reported associated with the use of some gadolinium-containing contrast agents in patients with severe renal impairment (GFR < 30ml/min/1.73m2): as there is a possibility of NSF occurring with ProHance, it should only be used in this type of patients after careful prior evaluation. In patients receiving haemodialysis therapy, haemodialysis may be useful immediately after ProHance administration to remove residual ProHance from the body.